Article
How rapidly does the human mitochondrial genome evolve?
American journal of human genetics - 1 Sept 1996
Howell N, Kubacka I, Mackey D A
Abstract excerpt
The results of an empirical nucleotide-sequencing approach indicate that the evolution of the human mitochondrial noncoding D-loop is both more rapid and more complex than is revealed by standard phylogenetic approaches. The nucleotide sequence of the D-loop region of the mitochondrial genome was determined for 45 members of a large matrilineal Leber hereditary optic neuropathy pedigree. Two germ-line mutations...
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