The genome-sequenced variant of Campylobacter jejuni NCTC 11168 and the original clonal clinical isolate differ markedly in colonization, gene expression, and virulence-associated phenotypes.

Abstract excerpt

The genome sequence of the enteric bacterial pathogen Campylobacter jejuni NCTC 11168 (11168-GS) was published in 2000, providing a valuable resource for the identification of C. jejuni-specific colonization and virulence factors. Surprisingly, the 11168-GS clone was subsequently found to colonize 1-day-old chicks following oral challenge very poorly compared to other strains. In contrast, we have found that the...

Topics

• Animals
• Caco-2 Cells
• Campylobacter jejuni
• Chickens
• Citric Acid Cycle
• DNA, Bacterial
• Electron Transport
• Gene Expression Profiling
• Gene Expression Regulation, Bacterial
• Genome, Bacterial
• Genotype
• Gluconeogenesis