Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combretastatins: from natural products to drug discovery

1 Jan 2003

Abstract excerpt

The combretastatins are a group of anti-mitotic agents isolated from the bark of the South African tree Combretum caffrum. The most potent member is combretastatin A-4, and this compound together with a phosphate pro-drug form have already progressed through into clinical trails for the treatment of solid tumours. What makes this class of compounds rather more interesting than other anti-mitotic agents is that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cancer Mechanisms and Therapy
Share to Phytochemical compounds biological activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14700199
DOI: 10.1039/b306797c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Combretastatins: from natural products to drug discoveryPMID 14700199Read ↗

Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive reviewSemantic proximity Read ↗

Design, synthesis and characterisation of potential anticancer agents based on natural products and studies on their biological effectSemantic proximity Read ↗

Convergent synthesis and biological evaluation of vitamin D analogues as potential anticancer agentsSemantic proximity Read ↗

Chemoenzymatic synthesis of prodigiosin analogues--exploring the substrate specificity of PigC.Semantic proximity Read ↗

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines.Semantic proximity Read ↗

Flavonoids as omnipotent candidates for cancer managementSemantic proximity Read ↗

Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against CancerSemantic proximity Read ↗

Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part II: Alkaloids, Terpenoids and FlavonoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.