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A pilot study of combination therapy with initial high-dose interferon and amantadine hydrochloride for patients with chronic hepatitis C with the genotype 1b virus.

Hepato-gastroenterology - 1 Jan 2000

Uyama Hirokazu, Enomoto Hirayuki, Kishima Yoshihiko, Yamamoto Mitsunari, Yoshida Kenya, Okuda Yorihide, Hirotani Tomonori, Kuroda Toshifumi, Ito Hiroaki, Matsuda Masahiro, Terabayashi Minoru, Noguchi Sanai, Kawase Ichiro, Nakamura Hideji

Abstract excerpt

BACKGROUND/AIMS: Interferon monotherapy for patients with chronic hepatitis C has been suboptimal. We studied the effect of the combination therapy of an initial high-dose of interferon and amantadine. METHODOLOGY: We investigated the virological response of 20 patients with naive chronic hepatitis C with a high viral load of the genotype 1b virus. Seven patients were administered 6MU of interferon-beta once...

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PMID: 14696476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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