Article
High-dose prolonged combination therapy in non-responders to interferon monotherapy for chronic hepatitis C.
Alimentary pharmacology & therapeutics - 1 Jul 2001
Di Marco V, Vaccaro A, Ferraro D, Alaimo G, Rodolico V, Parisi P, Peralta S, Di Stefano R, Almasio P L, Craxì A
Abstract excerpt
BACKGROUND: Therapy of chronic hepatitis C non- responders to interferon monotherapy with standard doses of interferon plus ribavirin is usually ineffective. AIM: To evaluate the efficacy and tolerability of high-dose prolonged combination retreatment in non- responder patients. METHODS: Patients were retreated for 6 months with 6 MU alphaIFN on alternate days and 1000 or 1200 mg/day ribavirin. HCV-RNA negative...
Topics
- Adult
- Antiviral Agents
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Resistance
- Drug Therapy, Combination
- Female
- Fibrosis
- Genotype
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Male