Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a variant of PAC-1 in large granular lymphocyte leukemia.

Protein expression and purification - 1 Nov 2003

Kothapalli Ravi, Yoder Sean J, Kusmartseva Irina, Loughran Thomas P

Abstract excerpt

Phosphatase in activated T cells (PAC-1) is a mitogen-induced early responsive gene. It encodes a 32 kDa tyrosine-threonine dual specificity phosphatase. Constitutive expression of PAC-1 leads to an inhibition of MAP kinase activity in vivo. Such constitutive expression was reported in HTLV-1 inf...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Expressed Sequence Tags
Share to Gene Library
Share to Immediate-Early Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphoid

Share to Phosphoprotein Phosphatases

Share to Protein Phosphatase 1

Share to Protein Phosphatase 2

Share to Protein Tyrosine Phosphatases

Source

Identifiers

PMID: 14680939
DOI: 10.1016/S1046-5928(03)00237-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14680939-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a variant of PAC-1 in large granular lymphocyte leukemia.PMID 14680939Read ↗

Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line.Semantic proximity Read ↗

Identification of human patatin-like phospholipase domain-containing protein 1 and a mutant in human cervical cancer HeLa cells.Semantic proximity Read ↗

A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.Semantic proximity Read ↗

Characterization of two spliced variants of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.Semantic proximity Read ↗

Rcho-1 trophoblast cell placental lactogens: complementary deoxyribonucleic acids, heterologous expression, and biological activities.Semantic proximity Read ↗

PLU‐1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen?Semantic proximity Read ↗

Properties of a novel gene isolated from a Hodgkin's disease cell line that is expressed early during lymphoid cell activation.Semantic proximity Read ↗

Transcriptional downregulation of the lactase (LCT) gene during childhoodSemantic proximity Read ↗

Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complexSemantic proximity Read ↗

Characterization by cDNA Cloning of Two New Human Protein KinasesSemantic proximity Read ↗

Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation.Semantic proximity Read ↗

Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.