Article
Molecular brain imaging and the neurobiology and genetics of schizophrenia.
Pharmacopsychiatry - 1 Nov 2003
Heinz A, Romero B, Gallinat J, Juckel G, Weinberger D R
Abstract excerpt
It has been hypothesized that schizophrenia is related to dysfunction in temporolimbic-prefrontal neuronal networks, which is acquired early in an individual's development. After puberty, relatively reduced prefrontal control of striatal dopaminergic neurotransmission may lead to unmodulated striatal dopamine (DA) activity, and the positive symptoms of acute psychosis. Brain imaging studies support the notion of...
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