Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus.

Endocrinology - 1 Apr 2004

Bouret Sebastien, De Seranno Sandrine, Beauvillain Jean-Claude, Prevot Vincent

Abstract excerpt

In vitro studies using immortalized GT1 cells suggest that hypothalamic astrocytes employ TGFbeta(1) to directly regulate the secretion of GnRH, the neurohormone that controls sexual maturation and adult reproductive function. However, whether such astrocyte-GnRH neuron signaling occurs in vivo is not clear. In the present study, we used in situ hybridization and immunohistochemistry to determine whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Gonadotropin-Releasing Hormone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypothalamus

Share to Rats, Wistar

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 14670985
DOI: 10.1210/en.2003-1468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus.PMID 14670985Read ↗

Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes.Semantic proximity Read ↗

The transforming growth factor‐β superfamily in early spermatogenesis: potential relevance to testicular dysgenesisSemantic proximity Read ↗

Glial cell-line-derived neurotropic factor and its receptors are expressed by germinal and somatic cells of the rat testisSemantic proximity Read ↗

Emerging roles for TGF‐β1 in nervous system developmentSemantic proximity Read ↗

erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function.Semantic proximity Read ↗

TGF-alpha induces a stationary, radial-glia like phenotype in cultured astrocytes.Semantic proximity Read ↗

Gonadotropin‐releasing hormone: GnRH receptor signaling in extrapituitary tissuesSemantic proximity Read ↗

Targeting transforming growth factor α expression to discrete loci of the neuroendocrine brain induces female sexual precocitySemantic proximity Read ↗

Glial fibrillary acidic protein gene promoter is differently modulated by transforming growth factor‐beta 1 in astrocytes from distinct brain regionsSemantic proximity Read ↗

Potential targets of transforming growth factor-beta1 during inhibition of oocyte maturation in zebrafishSemantic proximity Read ↗

Rapid TGFβ1 effects on actin cytoskeleton of astrocytes: Comparison with other factors and implications for cell motilitySemantic proximity Read ↗

Expression and regulation of gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acids in human granulosa-luteal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.