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Article

Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif.

The Journal of biological chemistry - 13 Feb 2004

Haggie Peter M, Stanton Bruce A, Verkman A S

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel expressed at the apical plasma membrane. It has been proposed that the C-terminal PDZ binding motif of CFTR is required for its apical membrane targeting and that PDZ-domain interactions may tether CFTR to the actin cytoskeleton via soluble proteins including EBP50/NHERF1 and ezrin. We measured the diffusional...

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Source

Identifiers

PMID: 14660592
DOI: 10.1074/jbc.M312445200

Genes

CFTR
NHERF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif.PMID 14660592Read ↗

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