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Article

Malaria parasites lacking eef1a have a normal S/M phase yet grow more slowly due to a longer G1 phase.

Molecular microbiology - 1 Dec 2003

Janse Chris J, Haghparast Alireza, Sperança Márcia A, Ramesar Jai, Kroeze Hans, del Portillo Hernando A, Waters Andrew P

Abstract excerpt

Eukaryotic elongation factor 1A (eEF1A) plays a central role in protein synthesis, cell growth and morphology. Malaria parasites possess two identical genes encoding eEF1A (eef1aa and eef1ab). Using pbeef1a-Plasmodium berghei mutants that lack an eEF1a gene, we demonstrate that the level of eEF1A production affects the proliferation of blood stages and parasite fitness. Pbeef1a- parasites can complete the...

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PMID: 14651637
DOI: 10.1046/j.1365-2958.2003.03820.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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