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Article

A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes.

Journal of human genetics - 1 Jan 2003

Peterlin Borut, Globočnik Petrovič Mojca, Makuc Jana, Hawlina Marko, Petrovič Daniel

Abstract excerpt

Iron metabolism might be involved in the pathogenesis of type 2 diabetes and in the pathogenesis of diabetic retinopathy. C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with increased serum iron levels and consequently with hereditary hemochromatosis. In the present study, we searched for a relationship between C282Y and H63D gene mutations and the development of proliferative diabetic...

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Source

Identifiers

PMID: 14618419
DOI: 10.1007/s10038-003-0094-3

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes.PMID 14618419Read ↗

Hemochromatosis gene (HFE) polymorphisms and risk of type 2 diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

A search for association between hereditary hemochromatosis HFE gene mutations and type 2 diabetes mellitus in a Polish population.Semantic proximity Read ↗

Lack of association of C282Y and H63D mutations in the hemochromatosis (HFE) gene with diabetes mellitus type 2 in a case-control study of women in Brazil.Semantic proximity Read ↗

Increased C282Y heterozygosity in gestational diabetes.Semantic proximity Read ↗

Prevalence of hereditary haemochromatosis in late-onset type 1 diabetes mellitus: a retrospective study.Semantic proximity Read ↗

Haemochromatosis-causing mutations C282Y and H63D are not risk factors for coronary artery disease in Caucasians with type 2 diabetes.Semantic proximity Read ↗

Diabetes in HFE Hemochromatosis.Semantic proximity Read ↗

Clinical expression and insulin sensitivity in type 2 diabetic patients with heterozygous mutations for haemochromatosis.Semantic proximity Read ↗

Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population.Semantic proximity Read ↗

The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis.Semantic proximity Read ↗

HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women.Semantic proximity Read ↗

The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2.Semantic proximity Read ↗

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