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Article

Variation of CAG repeats and two intragenic polymorphisms at SCA3 locus among Machado-Joseph disease/SCA3 patients and diverse normal populations from eastern India.

Acta neurologica Scandinavica - 1 Dec 2003

Chattopadhyay B, Basu P, Gangopadhyay P K, Mukherjee S C, Sinha K K, Chakraborty A, Roy T, Roychoudhury S, Majumder P P, Bhattacharyya N P

Abstract excerpt

OBJECTIVES: MJD1/SCA3 is the most common type of spinocerebellar ataxia (SCA) worldwide. To explain the low prevalence of the disease among SCA patients from eastern India, we analysed CAG repeats and two bi-allelic intragenic markers at SCA3 locus among 412 normal individuals and 10 patients. MATERIALS AND METHODS: For CAG repeat analysis, PCR amplified fragments were run on polyacrylamide gel, transferred to a...

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Ataxin-3
India
Machado-Joseph Disease
Nerve Tissue Proteins
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

Sampling Studies

Trinucleotide Repeats

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PMID: 14616293
DOI: 10.1034/j.1600-0404.2003.00167.x

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