Article
P300 and genetic risk for schizophrenia.
Archives of general psychiatry - 1 Nov 2003
Winterer Georg, Egan Michael F, Raedler Thomas, Sanchez Carmen, Jones Douglas W, Coppola Richard, Weinberger Daniel R
Abstract excerpt
BACKGROUND: We assessed the suitability of event-related potential frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies of schizophrenia. We applied a principal component analysis approach based on the notion that P300 abnormalities in siblings of schizophrenic patients may involve a widespread network of relatively weak cortical generators and because an earlier, smaller study...
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