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Signal pathway profiling of ovarian cancer from human tissue specimens using reverse‐phase protein microarrays

27 Oct 2003

Abstract excerpt

Defects in cell signaling pathways play a central role in cancer cell growth, survival, invasion and metastasis. An important goal of proteomics is to characterize and develop "circuit maps" of these signaling pathways in normal and diseased cells. We have used reverse-phase protein array technology coupled with laser capture microdissection and phospho-specific antibodies to examine the activation status of...

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PMID: 14595806
DOI: 10.1002/pmic.200300591

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