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Article

Temporal and Spatial Expression Profiles of BMP Receptors and Noggin During BMP-2-Induced Ectopic Bone Formation

1 Oct 2003

Abstract excerpt

UNLABELLED: The mechanism of ectopic bone formation has not been clear. After BMP-2 implantation into the back muscles of 198 mice, expression of BMPR-1A, -2, and Noggin was increased during the early phase of the reaction. The results suggest that positive and negative feedback mechanisms modulate ectopic osteogenesis induced by this growth factor. INTRODUCTION: The expression of bone morphogenetic protein...

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PMID: 14584896
DOI: 10.1359/jbmr.2003.18.10.1854

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