Article
[Evolution of the concept of mitochondrial disease].
Bulletin de l'Academie nationale de medecine - 1 Jan 2003
Desnuelle Claude
Abstract excerpt
The concept of mitochondrial disease originated in 1962 when Luft and co-workers described a patient with non thyroidal hypermetabolism related to loose coupling of oxidation-phosphorylation in muscle mitochondria. Over the following quarter of century, with the routine use of the Engel-Gomory staining on muscle biopsy revealing ragged-red fibres as a convenient markers for mitochondrial pathology, numerous...
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