Article
The FOXC2 -512C>T variant is associated with hypertriglyceridaemia and increased serum C-peptide in Danish Caucasian glucose-tolerant subjects.
Diabetologia - 1 Nov 2003
Yanagisawa K, Hingstrup Larsen L, Andersen G, Drivsholm T, Cederberg A, Westergren R, Borch-Johnsen K, Pedersen O, Enerbäck S, Hansen T
Abstract excerpt
AIMS/HYPOTHESIS: The transcription factor FOXC2 plays a key role in adipocyte differentiation and the FOXC2 gene is a candidate gene for Type 2 diabetes, obesity and dyslipidaemia. We investigated whether the FOXC2 -512C>T promoter variant is associated with Type 2 diabetes or its intermediary phenotypes in glucose tolerant subjects. METHODS: The variant was genotyped using PCR-RFLP in 705 unrelated Type 2...
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