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Article

Covariation of backbone motion throughout a small protein domain.

Nature structural biology - 1 Nov 2003

Mayer Kristen L, Earley Matthew R, Gupta Sonia, Pichumani Kumar, Regan Lynne, Stone Martin J

Abstract excerpt

The synchronization (correlation) of conformational fluctuations in folded proteins may influence the rates of enzyme catalysis and ligand binding as well as the stabilities of native proteins and their complexes. However, experimental detection of correlated motions remains difficult. Herein, we present an analysis of the covariation of NMR-derived backbone dynamical parameters among a family of ten mutants of a...

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PMID: 14528292
DOI: 10.1038/nsb991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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