Article
Molecular heterogeneity of meningioma with INI1 mutation.
Molecular pathology : MP - 1 Oct 2003
Rieske P, Zakrzewska M, Piaskowski S, Jaskólski D, Sikorska B, Papierz W, Zakrzewski K, Liberski P P
Abstract excerpt
BACKGROUND: INI1 (hSNF5) mutations are linked to rhabdoid tumours, but mutations in meningiomas with hot spot mutations in position 377 have also been reported. AIMS: To analyse the INI1 gene in meningioma. METHODS: Exons 1, 4, 5, and 9 of the INI1 gene were analysed by the polymerase chain reaction and direct sequencing in 80 meningiomas. For all cases, western blotting of the INI1 protein was performed....
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