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Article

Detecting functional interactions in a gene and signaling network by time-resolved somatic complementation analysis.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 2003

Marwan Wolfgang

Abstract excerpt

Somatic complementation by fusion of two mutant cells and mixing of their cytoplasms occurs when the genetic defect of one fusion partner is cured by the functional gene product provided by the other. We have found that complementation of mutational defects in the network mediating stimulus-induced commitment and sporulation of Physarum polycephalum may reflect time-dependent changes in the signaling state of its...

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PMID: 14505362
DOI: 10.1002/bies.10342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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