Article
Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3.
Thrombosis and haemostasis - 1 Sept 2002
Nair Sona, Li Jihong, Mitchell W Beau, Mohanty Dipika, Coller Barry S, French Deborah L
Abstract excerpt
New mutations in the beta3 integrin subunit have been identified in two unrelated Glanzmann thrombasthenia patients originating from India and Bangladesh. Both patients had histories of excessive bleeding and were found to have Glanzmann thrombasthenia based on absent ADP-induced platelet aggregation. Immunoblotting of platelet lysates of Patient 1 demonstrated reduced levels of alphaIIb and an unexpected high Mr...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.