Article
MELAS syndrome with mitochondrial tRNA(Leu)(UUR) mutation: correlation of clinical state, nerve conduction, and muscle 31P magnetic resonance spectroscopy during treatment with nicotinamide and riboflavin.
Neurology - 1 Nov 1992
Penn A M, Lee J W, Thuillier P, Wagner M, Maclure K M, Menard M R, Hall L D, Kennaway N G
Abstract excerpt
We report a patient with mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes treated with riboflavin and nicotinamide for 18 months, during which time previously frequent encephalopathic spells ceased. To confirm clinical benefit, we withdrew treatment and monitored response...
Topics
- Adult
- Drug Therapy, Combination
- Female
- Humans
- MELAS Syndrome
- Magnetic Resonance Spectroscopy
- Mitochondria, Muscle
- Muscles
- Mutation
- Neural Conduction
- Niacinamide
- Phosphates
- RNA, Transfer, Leu
- Riboflavin