Spontaneous chromosome rearrangements in the protozoan Giardia lamblia: estimation of mutation rates.

doi:10.1093/nar/20.17.4539

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Spontaneous chromosome rearrangements in the protozoan Giardia lamblia: estimation of mutation rates.

Nucleic acids research - 11 Sept 1992

Le Blancq S M, Korman S H, Van der Ploeg L H

Abstract excerpt

Subcloned lines of the WB strain of Giardia lamblia contain polymorphic ribosomal RNA (rRNA) encoding chromosomes (Le Blancq et al., Nucl. Acids Res. 1991, 19, 4405-4412). We show that in a continuously propagated culture of G.lamblia trophozoites the proportion of trophozoites with rearranged rRNA encoding chromosomes gradually increases, consistent with the high mutation rate of about 1% per cell per division...

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