Article
Spontaneous chromosome rearrangements in the protozoan Giardia lamblia: estimation of mutation rates.
Nucleic acids research - 11 Sept 1992
Le Blancq S M, Korman S H, Van der Ploeg L H
Abstract excerpt
Subcloned lines of the WB strain of Giardia lamblia contain polymorphic ribosomal RNA (rRNA) encoding chromosomes (Le Blancq et al., Nucl. Acids Res. 1991, 19, 4405-4412). We show that in a continuously propagated culture of G.lamblia trophozoites the proportion of trophozoites with rearranged rRNA encoding chromosomes gradually increases, consistent with the high mutation rate of about 1% per cell per division...
Topics
- Animals
- Chromosomes
- DNA Probes
- DNA, Protozoan
- DNA, Ribosomal
- Electrophoresis, Gel, Pulsed-Field
- Giardia lamblia
- Mathematics
- Mutation
- RNA, Ribosomal
- Recombination, Genetic