Article
An intrinsic neuronal defect operates in dystonia musculorum: a study of dt/dt<==>+/+ chimeras.
Neuron - 1 Oct 1992
Campbell R M, Peterson A C
Abstract excerpt
In the mouse mutant dystonia musculorum (dt), peripheral and central sensory axons develop focal swellings and degenerate. To identify the primary cellular target of the mutation, we have analyzed the spinal cords of dt/dt<==>+/+ aggregation chimeras. In these chimeras, characteristic swellings appeared only on the axons of mutant genotype neurons; the axons of wild-type neurons, identified by their expression of...
Topics
- Animals
- Antibodies, Monoclonal
- Axons
- Chimera
- Embryo, Mammalian
- Genotype
- Immunohistochemistry
- Intermediate Filaments
- Mice
- Mice, Neurologic Mutants
- Mutation
- Nerve Degeneration