Chronic lymphocytic leukemia/small lymphocytic lymphoma with Reed-Sternberg-like cells and possible transformation to Hodgkin's disease. Mediation by Epstein-Barr virus.

doi:10.1097/00000478-199209000-00004

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Article

Chronic lymphocytic leukemia/small lymphocytic lymphoma with Reed-Sternberg-like cells and possible transformation to Hodgkin's disease. Mediation by Epstein-Barr virus.

The American journal of surgical pathology - 1 Sept 1992

Momose H, Jaffe E S, Shin S S, Chen Y Y, Weiss L M

Abstract excerpt

The pathogenesis of Reed-Sternberg cells and variants (RS-H cells) found in rare cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is unknown. We studied 13 such cases by immunohistochemistry and in situ hybridization for identification of Epstein-Barr virus (EBV) RNA. The RS-H cells in five cases expressed the B-lineage marker CD20 and were negative for CD15. In two cases, the RS-H cells...

Topics

Adult
Aged
Aged, 80 and over
Antigens, CD
Antigens, CD20
Antigens, Differentiation, B-Lymphocyte
Cell Transformation, Neoplastic
DNA, Viral
Female
Herpesvirus 4, Human

Hodgkin Disease

Humans

Immunohistochemistry

Leukemia, Lymphocytic, Chronic, B-Cell

Lewis X Antigen

Male

Middle Aged

Nucleic Acid Hybridization

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