Article
Recombinant human granulocyte colony-stimulating factor enhanced cytotoxicity of Ara-C in Ara-C-resistant leukemic cells from a patient with biphenotypic leukemia in cell kinetic quiescence.
Leukemia research - 1 Oct 1992
Higashigawa M, Komada Y, Washio N, Kuwabara H, Hori H, Ido M, Sakurai M
Abstract excerpt
In vitro preincubation with recombinant granulocyte colony-stimulating factor(rhG-CSF, 100 ng/ml) enhanced the cytotoxicity of 1-beta-D-arabinofuranosylcytosine(Ara-C) in leukemic cells resistant to Ara-C from a patient with biphenotypic leukemia. Treatment of the cells with rhG-CSF resulted in a 17-fold increase in DNA synthesis, 4.6-fold increase in percentage of S-phase, and a two-fold increase in Ara-CTP...
Topics
- Cell Cycle
- Cell Division
- Child
- Cytarabine
- DNA
- Dose-Response Relationship, Drug
- Drug Resistance
- Drug Synergism
- Drug Therapy, Combination
- Female
- Granulocyte Colony-Stimulating Factor