Article
Effect of neonatal exposure to 5-bromo-2'-deoxyuridine on life span, estrus function and tumor development in rats--an argument in favor of the mutation theory of aging?
Mutation research - 1 Mar 1992
Anisimov V N, Osipova GYu
Abstract excerpt
Outbred LIO rats were exposed to subcutaneous injections (3.2 mg) of a synthetic analogue of thymidine, 5-bromo-2'-deoxyuridine (BrdUrd), on days 1 and 3, or days 1, 3, 7 and 21 of postnatal life. The mean life span decreased by 31% and 38% in male and by 14% and 27% in female rats that received...
Topics
- Aging
- Animals
- Animals, Newborn
- Body Weight
- Bromodeoxyuridine
- Chromosome Aberrations
- Chromosome Disorders
- Estrus
- Female
- Longevity
- Male
- Mutation
- Neoplasms, Experimental
- Organ Size
- Ovariectomy
- Pituitary Gland, Anterior
- Rats