Article
Three cell lines showing androgen-dependent, -independent, and -suppressed phenotypes, established from a single tumor of androgen-dependent Shionogi carcinoma 115.
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 Apr 1992
Yamaguchi T, Kawamoto K, Uchida N, Uchida K, Watanabe S
Abstract excerpt
We investigated the heterogeneity of cells in terms of androgen responsiveness within a single tumor mass of Shionogi carcinoma SC-115 showing androgen-dependent growth. After cloning of the tumor by the limiting dilution method in the presence of androgen, we isolated 40 clones at random. Twenty...
Topics
- Androgens
- Animals
- Antibodies
- Cell Division
- Epidermal Growth Factor
- Fibroblast Growth Factor 1
- Fibroblast Growth Factor 2
- Male
- Mammary Neoplasms, Experimental
- Mice
- Phenotype
- Testosterone
- Transforming Growth Factor alpha
- Tumor Cells, Cultured