Article
Mak5p, which is required for the maintenance of the M1 dsRNA virus, is encoded by the yeast ORF YBR142w and is involved in the biogenesis of the 60S subunit of the ribosome.
Molecular genetics and genomics : MGG - 1 Nov 2003
Zagulski M, Kressler D, Bécam A-M, Rytka J, Herbert C J
Abstract excerpt
In this study, we show that the Saccharomyces cerevisiae ORF YBR142w, which encodes a putative DEAD-box RNA helicase, corresponds to MAK5. The mak5-1 allele is deficient in the maintenance of the M1 dsRNA virus, resulting in a killer minus phenotype. This allele carries two mutations, G218D in the conserved ATPase A-motif and P618S in a non-conserved region. We have separated these mutations and shown that it is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.