Article
[The molecular genetics of meningiomas and genotypic/phenotypic correlations].
Revue neurologique - 1 Sept 2003
Dezamis E, Sanson M
Abstract excerpt
The WHO classification divides meningiomas in three grades. In grade 1 tumors, by far the most common (90 p. cent), inactivation of the NF2 gene (associated to the loss of chromosome 22) is the most frequent alteration. However, a subset of grade 1 meningiomas does not involve the NF2 gene and is less likely to evolve towards higher grade tumors. After NF2 inactivation, additional events may occur and are related...
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