Article
Ethanol-induced CD3 and CD2 hyporesponsiveness of peripheral blood T lymphocytes.
Immunopharmacology and immunotoxicology - 1 Jan 1992
Spinozzi F, Agea E, Fiorucci G, Gerli R, Muscat C, Belia S, Bertotto A
Abstract excerpt
The functional relevance of a direct ethanol effect on the membrane structure of T lymphocytes and accessory cells (APC), as well as on signal transduction systems was studied in ten normal subjects. Ethanol incubation (80 mM for 24h) of highly purified T cells increased the number of CD4+/CD45RA+ lymphocytes. In contrast, ethanol exposure induced a drop in CD14+/LFA-3+ APC values. These changes were accompanied...
Topics
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- Antigens, Differentiation, T-Lymphocyte
- CD2 Antigens
- CD3 Complex
- Calcium
- Ethanol
- Humans
- Inositol 1,4,5-Trisphosphate
- Intracellular Fluid
- Lymphocyte Activation