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Article

[Contribution of molecular genetics to the understanding of chemoresistance of Plasmodium falciparum].

Bulletin de la Societe de pathologie exotique (1990) - 1 Jan 1992

Le Bras J, Basco L K, Cremer G, Charmot G

Abstract excerpt

Resistance to pyrimethamine and proguanil is due to a single point mutation in the gene that codes for dihydrofolate reductase. A single mutation gives rise to resistance to only one of the drugs. Resistance to both drugs results from several mutations. Chloroquine resistance phenotype is due to...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Chloroquine
Drug Resistance
Folic Acid Antagonists
Membrane Glycoproteins
Molecular Biology
Mutation
Plasmodium falciparum
Pyrimethamine
Triazines

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PMID: 1356539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1356539-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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