Article
Depression as a consequence of inadequate neurochemical adaptation in response to stressors.
The British journal of psychiatry. Supplement - 1 Feb 1992
Anisman H, Zacharko R M
Abstract excerpt
Stressors induce behavioural disturbances and neurochemical changes in animals, some of which are reminiscent of the symptoms and presumed neurochemical concomitants of depression in humans. Just as in humans, where considerable inter-individual variability is evident in the symptom profile of depression, there is marked inter-individual and inter-strain variability in the behavioural effects of stressors in...
Topics
- Adjustment Disorders
- Animals
- Arousal
- Brain
- Depressive Disorder
- Disease Models, Animal
- Helplessness, Learned
- Humans
- Mice
- Mice, Inbred Strains
- Neurotransmitter Agents