Article
Genetic analysis of susceptibility to radiation-induced apoptosis of thymocytes in mice.
International journal of radiation biology - 1 Aug 1992
Mori N, Okumoto M, Morimoto J, Imai S, Matsuyama T, Takamori Y, Yagasaki O
Abstract excerpt
Genetic control of thymocyte susceptibility to radiation-induced apoptosis was investigated in BALB/cHeA, STS/A and five other strains of mice by counting pyknotic cells in a selected area of thymic cortex on histological specimens after whole-body X-irradiation. Number of dead cells increased almost linearly with doses (range 0.25-0.75 Gy) in BALB/cHeA and STS/A mice. However, dead cell counts in BALB/cHeA mice...
Topics
- Animals
- Cell Death
- Dose-Response Relationship, Radiation
- Female
- Male
- Mice
- Mice, Inbred Strains
- Phenotype
- Thymus Gland
- Time Factors
