Article
Constitutional ring chromosomes and tumour suppressor genes.
Journal of medical genetics - 1 Dec 1992
Tommerup N, Lothe R
Abstract excerpt
The types of malignancy reported in carriers of constitutional ring chromosomes r(11), r(13), and r(22) are concordant with the chromosomal assignment of tumour suppressor loci associated with Wilms' tumour, retinoblastoma, and meningioma. It is suggested that the somatic instability of ring chromosomes may play a role in this association and that constitutional ring chromosomes may be a source for mapping of...
Topics
- Adenocarcinoma
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 22
- Genes, Tumor Suppressor
- Humans
- Male
- Mosaicism
- Mutation