Article
Effect of interstrain variation on diagnostic DNA amplification of the cytomegalovirus major immediate-early gene region.
Journal of clinical microbiology - 1 Sept 1992
Chou S
Abstract excerpt
The immediate-early region exon 4 sequences of six clinical cytomegalovirus strains were determined and compared with those of laboratory strains AD169 and Towne. Of 407 codons in exon 4, 33 (8.1%) showed interstrain variation at the peptide level and 74 (18%) showed interstrain variation at the nucleotide level. Variation occurred sporadically throughout the exon, and no grouping of strains was apparent....
Topics
- Base Sequence
- Cytomegalovirus
- Cytomegalovirus Infections
- DNA, Single-Stranded
- DNA, Viral
- Exons
- Genes, Viral
- Genetic Variation
- Molecular Sequence Data
- Polymerase Chain Reaction
- Sensitivity and Specificity