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Article

Decreased function of the class B tetracycline efflux protein Tet with mutations at aspartate 15, a putative intramembrane residue.

Journal of bacteriology - 1 Oct 1992

McMurry L M, Stephan M, Levy S B

Abstract excerpt

The aspartate 15 residue within the first predicted intramembrane helix of the tetracycline efflux protein Tet has been conserved in four tetracycline resistance determinants from gram-negative bacteria. Its replacement in class B Tet by tyrosine, histidine, or asparagine resulted in a 60 to 85%...

Topics

Aspartic Acid
Base Sequence
Carrier Proteins
Escherichia coli
Membrane Proteins
Molecular Sequence Data
Mutation
Protons
R Factors
Repressor Proteins
Restriction Mapping
Structure-Activity Relationship

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Tetracycline

Tetracycline Resistance

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Identifiers

PMID: 1328154
DOI: 10.1128/jb.174.19.6294-6297.1992
PMCID: PMC207700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1328154-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Decreased function of the class B tetracycline efflux protein Tet with mutations at aspartate 15, a putative intramembrane residue.PMID 1328154Read ↗

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