Article
delta-Aminolevulinate couples cycA transcription to changes in heme availability in Rhodobacter sphaeroides.
Journal of molecular biology - 5 Jul 1992
Schilke B A, Donohue T J
Abstract excerpt
In this paper, the response of the transcriptional control region of the Rhodobacter sphaeroides cytochrome c2 gene, cycA, to intermediates in heme biosynthesis was studied. To determine if cycA transcription was regulated by heme availability, several precursors or analogs of tetrapyrroles were tested. Addition of delta-aminolevulinate (ALA), the first committed intermediate in heme biosynthesis, was shown to...
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