Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model.

International journal of oncology - 1 Oct 2003

Horiuchi Hideki, Kawamata Hitoshi, Fujimori Takahiro, Kuroda Yoshikazu

Abstract excerpt

Most cases of gallbladder cancer are found at an advanced stage accompanied by invasion to the liver, metastases to the lymph nodes and distant organs, and peritoneal dissemination. Then, the treatment for advanced gallbladder cancer is often ineffective, and the prognosis of this disease is poor. The specific aim of this study was to establish a model system for developing new therapeutic strategies, such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butadienes
Share to Gallbladder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gallbladder Neoplasms

Share to Mice, Nude

Share to Mitogen-Activated Protein Kinases

Share to Neoplasm Metastasis

Share to Neoplasm Transplantation

Share to Nitriles

Source

Identifiers

PMID: 12963974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model.PMID 12963974Read ↗

Establishment and characterization of a cell line, EH-GB2, derived from hepatic metastasis of gallbladder cancer.Semantic proximity Read ↗

Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing.Semantic proximity Read ↗

Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells.Semantic proximity Read ↗

Isolation of a human gallbladder cancer cell clone with high invasive phenotype in vitro and metastatic potential in orthotopic model and inhibition of its invasiveness by heparanase antisense oligodeoxynucleotides.Semantic proximity Read ↗

Baicalin Induces Apoptosis of Gallbladder Carcinoma Cells in vitro via a Mitochondrial-Mediated Pathway and Suppresses Tumor Growth in vivoSemantic proximity Read ↗

Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters.Semantic proximity Read ↗

SP/NK‐1R promotes gallbladder cancer cell proliferation and migrationSemantic proximity Read ↗

The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.