Usefulness of polymorphic markers in exclusion of BRCA1/BRCA2 mutations in families with aggregation of breast/ovarian cancers.

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Usefulness of polymorphic markers in exclusion of BRCA1/BRCA2 mutations in families with aggregation of breast/ovarian cancers.

Journal of applied genetics - 1 Jan 2003

Górski Bohdan, Debniak Tadeusz, Jakubowska Anna, Cybulski Cezary, Huzarski Tomasz, Byrski Tomasz, Złowocka Elzbieta, Lubiński Jan

Abstract excerpt

Founder mutations can account for a large proportion of BRCA1/BRCA2 gene abnormalities in a given population. However there is still a need to study the entire gene in many families, even in countries where founder mutations have been identified. It is possible to decrease the number of cases whi...

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Usefulness of polymorphic markers in exclusion of BRCA1/BRCA2 mutations in families with aggregation of breast/ovarian cancers.

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