Article
Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.
International journal of cancer - 10 Oct 2003
Matsumoto Koji, Yasugi Toshiharu, Nakagawa Shunsuke, Okubo Mitsuo, Hirata Ranko, Maeda Hiroo, Yoshikawa Hiroyuki, Taketani Yuji
Abstract excerpt
The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence...
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