Article
Sampling and repeatability in the evaluation of hepatitis C virus genetic variability.
The Journal of general virology - 1 Sept 2003
Torres-Puente Manuela, Bracho M Alma, Jiménez Nuria, García-Robles Inmaculada, Moya Andrés, González-Candelas Fernando
Abstract excerpt
Among the experimental techniques available to study the genetic variability of RNA virus populations, the most informative involve reverse transcription (RT), amplification, cloning and sequencing. The effects of several aspects of these techniques on the estimation of genetic variability in a virus population were analysed. Hepatitis C virus populations from four patients were examined. For each patient, ten...
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