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Article

Molecular characterization of an inherited ring (19) demonstrating ring opening

23 Apr 2003

Abstract excerpt

Ring chromosomes arise following breakage in both chromosome arms and rejoining of the centric segment at the broken ends or by end-to-end fusion of the telomeres. The phenotype of ring carriers is unpredictable, and developmental abnormalities may occur even when the ring appears to be structurally balanced. This is believed to be due to mitotic instability from abnormal segregation and sister chromatid exchange...

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Share to Chromosomal and Genetic Variations
Share to Genomic variations and chromosomal abnormalities
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 12910493
DOI: 10.1002/ajmg.a.20184

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