Article
Evidence that postnatal growth retardation in XO mice is due to haploinsufficiency for a non-PAR X gene.
Cytogenetic and genome research - 1 Jan 2002
Burgoyne P S, Ojarikre O A, Turner J M A
Abstract excerpt
XO Turner women, irrespective of the parental source of the X chromosome, are of short stature, and this is now thought to be largely a consequence of haploinsufficiency for the pseudoautosomal region (PAR) gene SHOX. X(p)O mice (with a paternal X) are developmentally retarded in fetal life, are underweight at birth, and show reduced weight gain in the first few weeks after birth. X(m)O mice, on the other hand,...
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