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Article

A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly.

Archives of general psychiatry - 1 Sept 1999

Andreasen N C

Abstract excerpt

inding a unifying concept behind the diversity of signs and symptoms in schizophrenia is a central challenge to contemporary research. A neo-Bleulerian unitary model is described, which defines the illness as a neurodevelopmentally derived "misconnection syndrome," involving connections between cortical regions and the cerebellum mediated through the thalamus (the cortico-cerebellar-thalamic-cortical circuit...

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Identifiers

PMID: 12884883
DOI: 10.1001/archpsyc.56.9.781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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