Article
AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003
Schumann Uwe, Wanner Gerhard, Veenhuis Marten, Schmid Markus, Gietl Christine
Abstract excerpt
In yeasts and mammals, PEX10 encodes an integral membrane protein with a C3HC4 RING finger motif in its C-terminal domain and is required for peroxisome biogenesis and matrix protein import. In humans, its dysfunction in peroxisome biogenesis leads to severe Zellweger Syndrome and infantile Refsum disease. Here we show that dysfunction of a homologous gene in Arabidopsis leads to lethality at the heart stage of...
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