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Article

Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.

The Journal of biological chemistry - 17 Oct 2003

van der Slot Annemarie J, Zuurmond Anne-Marie, Bardoel Alfons F J, Wijmenga Cisca, Pruijs Hans E H, Sillence David O, Brinckmann Jürgen, Abraham David J, Black Carol M, Verzijl Nicole, DeGroot Jeroen, Hanemaaijer Roeland, TeKoppele Johan M, Huizinga Tom W J, Bank Ruud A

Abstract excerpt

The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited collagen shows an increase in pyridinoline cross-links, which are derived from hydroxylated lysine residues within the telopeptides. This change in cross-linking is related to irreversible accumulation of collagen in fibrotic tissues. The increase in pyridinoline cross-links is likely to be the result of increased activity...

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Source

Identifiers

PMID: 12881513
DOI: 10.1074/jbc.M307380200

Genes

PLOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.PMID 12881513Read ↗

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