Article
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003
Sorlie Therese, Tibshirani Robert, Parker Joel, Hastie Trevor, Marron J S, Nobel Andrew, Deng Shibing, Johnsen Hilde, Pesich Robert, Geisler Stephanie, Demeter Janos, Perou Charles M, Lønning Per E, Brown Patrick O, Børresen-Dale Anne-Lise, Botstein David
Abstract excerpt
Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we have refined the previously defined subtypes of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534...
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