Article
Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia.
Dementia and geriatric cognitive disorders - 1 Jan 2003
Zekanowski Cezary, Pepłońska Beata, Styczyńska Maria, Gustaw Katarzyna, Kuźnicki Jacek, Barcikowska Maria
Abstract excerpt
Frontotemporal dementia (FTD) is a common neurodegenerative disorder and is connected with about 10% of all dementias. In approximately half of all FTD cases, a positive family history has been reported. To date, several mutations at the tau protein gene (MAPT) were identified causing familial and sporadic FTD. Extensive polymorphic variability at the MAPT gene has also been shown to be a risk factor in...
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