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Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3.

Investigative ophthalmology & visual science - 1 Jul 2003

Morand Sabine, Buchillier Valérie, Maurer Fabienne, Bonny Christophe, Arsenijevic Yvan, Munier Francis L, Schorderet Daniel F

Abstract excerpt

PURPOSE: To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells. METHODS: Six mutations known to be responsible for autosomal dominant corneal dystrophies linked to chromosome 5 were generated in a BIGH3 expression vector and transfected in HeLa and HCE cells. The expression and secretion of the various BIGH3-EGFP fusion proteins were measured by Western blot...

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PMID: 12824240
DOI: 10.1167/iovs.02-0661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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